Aims and Objective: To study the histomorphological spectrum of non-neoplastic and neoplastic lesions of the Prostatic TURP specimens and analyse the utility of immunohistochemical marker P504S in various lesions of prostate. Methods: This two-year prospective study on 65 transurethral resection specimens of prostate, was carried out in the Department of pathology, Dr B R Ambedkar Medical College, Bangalore. Immunohistochemical marker P504S was used and its expression in various lesions was analysed