Background: Asthmatic patients have a TH2-predominant milieu that is associated with humoral immunity. However, little is detected about whether humoral immune responses to viral antigens differ between asthmatic and non-asthmatic children. This study aims to compare the humoral immune response to Measles-Mumps-Rubella (MMR) vaccine in asthmatic children and healthy controls. Methods: This case control study was conducted in Allergy and Immunology Centre; VACSERA. It included 90 children who received two doses of MMR vaccine, aged from 2 to 5 years where 45 asthmatic children were diagnosed using GINA diagnosis & classification criteria and compared to 45 age and sex matched controls. Mean titres of MMR specific IgG levels were determined using an enzyme-linked immunosorbent assay. Results; Lower levels of measles, rubella and mumps were found among asthmatic children than controls but were not statistically significant. Lower level of circulating measles specific IgG correlated with asthma severity. There was statistically significant lower level of circulating mumps specific IgG in preterm children among both cases and controls. Conclusion; Asthmatic children showed lower mean antibody levels for the measles, mumps and rubella vaccination compared to controls.