Background: Bruxism was generally deliberated as a contraindication for oral implanting. The fundamental relationship amid bruxism and dental implant failure has remained debatable in current literatures. Purpose: This meta-examination was performed to explore the connection between them. Materials and Methods: This review directed an electronic systematic literature search in MEDLINE (PubMed) and EmBase. Methodological quality was evaluated by using the Newcastle-Ottawa Scale tool. Odds ratio (OR) with 95% confidence interval (CI) was pooled to estimate the relative outcome of bruxism on dental implant failures. Statistical analyses done by using Review Manager 5.1. Results: The extracted data were categorized into two groups. Units were created on the number of prostheses (group A) and the number of patients (group B). In group A, the total pooled OR of bruxers versus nonbruxers for all subgroups was 4.72 (95% CI: 2.66- 8.36, p = .07). In group B, the total pooled OR of bruxers versus nonbruxers for all subgroups was 3.83 (95% CI: 2.12-6.94, p = .22). Conclusions: We found that Prostheses in bruxers had a higher failure rate. Our analysis advocates that bruxism is a contributing factor for the occurrence of dental implant technical/biological complications and may lead to dental implant failure.