Abstract. Echinococcus (Echinococcus granulosus) is a parasitic disease that occurs in some mammals and humans, is transmitted orally, infects human parenchymal organs (liver, lungs, spleen, and various other organs), and is chronic, causing echinococcal vomiting. The Republic of Uzbekistan is an endemic area for echinococcosis. According to official data, the damage rate is 6-9 people per 100,000 population. The number of surgeries performed annually due to echinococcosis ranges from 1,000 to 1,500. The article provides an analysis of the prevalence of echinococcosis among humans and animals, the long-term (1994-2019) dynamics of echinococcosis among the population of the Republic of Uzbekistan, routes of transmission, infectious factors, epidemiological and epizootiological features.