Abstract The methods of control and assessment of professional risk applied in the republic do not include the method of assessment of the degree of impact of harmful and dangerous factors of working conditions on specific employees, as well as the analysis of actual loss of working capacity of employees after long periods of labor activity. As a result of incorrectly chosen assessment methods and methodological approach, working conditions have a high risk of developing professional and professionally conditioned morbidity among groups of professions in industries. The purpose of this work was to determine the improved approaches to professional risk assessment and instrumental control over their implementation. Assessment of workers' health indicators depending on working conditions at the workplace is based on recommendations of the International Labor Organization. We have developed a package of normative and methodical documents, including 14 methodical recommendations, as well as Sanitary Rules and Norms, providing requirements to the hygienic assessment of the impact of various physical, chemical and biological factors on the health of workers. Conclusions were made to integrate the characteristics of the factors of working conditions through the transition from the normalization of individual parameters of the factors to complex indicators, changing the methodology of recording the working conditions at the working places to ensure a comprehensive assessment of all risks in a single procedure and their systematic monitoring. The use of modern software complexes as part of special devices for instrumental measurements have a loaded algorithm of measurements, pre-compiled a special computer program control planning, which offers the performer an operational hint on the choice of place and number of measuring points.