Background: Many anesthetic pre-medications are used to relieve this stress response. Of these premedications, midazolam and dexmedetomidine are effectively used as sedatives. The present study was planned to compare intranasal dexmedetomidine with intranasal midazolam as a pre-anesthetic medication in children. Many anaesthetic pre-medications are used to relieve this stress response. Of these pre-medications, midazolam and dexmedetomidine are effectively used as sedatives. The present study was planned to compare intranasal dexmedetomidine with intranasal midazolam as a pre-anesthetic medication in children. Fear of unpleasant and painful procedures, separation from parents and unwillingness to breathe through an anaesthesia face mask may produce stormy anaesthetic induction in unpremeditated patients. Because of this premedication should be an integral part of paediatric anaesthetic practice