Home-based accidents that occur in and around the home are of major concern among the parents of children below 5 years of age. Many children of pre-school age end up in hospitals after serious injuries due to common accidents like falls, burns, scalds, swallowing objects, etc. The purpose of the study was to assess the relationship of knowledge and self-declared practices of parents regarding home-based accidents and its prevention among pre-school children. A nonexperimental descriptive approach with survey method was adopted. Parents of 200 children within the age group of 3-5yrs were selected conveniently as the study sample. A self-structured questionnaire was used to collect the data. Results suggested that 24% of parents had extremely good knowledge regarding home-based accidents and 25.5% of parents are good in self-declared practices. Knowledge had no statistical association with age and had a statistical association withother selected demographic variables such as education of parents, number of children and type of family, and also statistical association was found between self-declared practices and selected demographic variables (p > 0.05). The study concluded that though there is no relationship between knowledge and practices to prevent home-based accidents practices are influenced by various factors. Hence more sensitization is required to strengthen the parents to prevent various home-based accidents which are more prevalent among the pre-school children.