Complementary and Alternative Therapy usage is increasing throughout the world. Complementary therapies are used to Complement conventional health care practices. A Quantitative research study with descriptive correlational research design was conducted among 300 clinical nurses by using convenient sampling technique to find out Knowledge,Attitude and perceived Barriers during patient care at selected hospitals of Bhubaneswar, Odisha. Samples who met the inclusion criteria were taken for study.The tool like Self-structured socio-demographic performa was used to collect sociodemographic data and self-structured Multiple choice questionnaire on Knowledge and self-structured five-point Likert scale was used to assess the Attitude and perceived Barriers of clinical nurses.The findings of this study show that maximum 63% nurses had Average knowledge on CAT, maximum 93% nurses had neutral attitude and maximum 77% nurses had faced intermediate perceived barriers in the integration of CAT during patient care. The result of the study describes it that there was a significant relationship exist between knowledge and belief of clinical nurses in integrating CAT during patient care as the ‛P᾽ Value is 0.001 and r value is 0.846 Which is Statistically Significant at the 0.01 level. There was a significant association between knowledge, Attitude and perceived Barriers with Area of working in a place and professional qualification in nursing of the clinical nurses. There was a significant association between perceived Barriers with professional qualification in nursing of the clinical nurses. The results of the present study concluded that the clinical nurses had average knowledge and neutral attitude to integrate CAT which also affected by perceived barriers of clinical nurses on CAT during patient care. The study has several implications in nursing education, practice and research. Further study can be conducted with a large sample of different groups of samples with different departments of the hospital.