Abstract To explore the possibilities of different methods of surgical treatment of severe acute pancreatitis , two groups of surgical patients were selected depending on the method of surgical treatment, which were produced by different types of " open " and laparoscopic operations. To assess the effectiveness of the applied methods of treatment, in the postoperative period, we used the following laboratory and physiological parameters: progression or regression systemic inflammatory response syndrome (SIRS ), neutro phil-lymphocyte ratio ( NLR), as well as integral scales for assessing severity Ranson , APACHE - II and SAPS . The results obtained demonstrate the advantages of laparoscopic surgical methods.