Abstract: The prevalence, clinical and pathological features of Gestational trophoblastic disease (GTD) was studied. GTD is a term that unites a group of pathological conditions associated with pregnancy that develop as a result of abnormal cell proliferation of the trophoblast after fertilization. The aim of the research was to study the clinical and pathological features and the prevalence of various forms of gestational trophoblastic disease in Uzbekistan. A retrospective analysis of the case histories of women with gestational trophoblastic disease was carried out.As a result of the research, the following conclusions were made: there is a tendency to increase the incidence of gestational trophoblastic disease. Established the single center for monitoring, diagnostics and treatment of trophoblastic disease in the republic will improve the quality of diagnosis, treatment and rehabilitation of this category of patients. It is necessary to use markers to predict the malignant transformation of trophoblastic disease using modern diagnostic methods.