Background: Pregnancy and puerperium is a critical period where many physiological changes take place involving various systems. These changes can result in neurological and hemodynamic disturbances and may sometimes lead to serious adverse effects if prompt treatment is not undertaken. Material and methods: Fifty post partum patients with clinical suspicion of neurological disorders referred to the Department of Medicine, AIIMS, New Delhi, from August 2019 to June 2022 underwent MRI of brain. The main source of data for the study were patients from All India institute of medical sciences, New Delhi. Conclusion: MRI was found to be a key modality to evaluate various neurological disorders and to arrive at an accurate diagnosis. Characterization of the lesions and awareness of the common diseases during puerperium will help the clinician arrive at an informed differential diagnosis. MRI is a non-invasive imaging modality with no radiation hazard, excellent resolution and multiplanar imaging capability