Online ISSN: 2515-8260

Malat1 RNA Genetic Factor and T1 Bladder Cancer

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Vladimir F. Kulikovsky1,4, Viktor K. Gostishchev1 , Alexander F. Chernousov1 , Pavel G. Osipov1,2, Andrey L. Yarosh1,4, Uriy A. Hoschenko1,3 , Olesya I. Lokteva1 , Andrey A. Beresh1,2


ABSTRACT Bladder cancer is the most common malignant tumor of the urinary tract. This disease has a pronounced tendency to relapse and progress, is characterized by a severe course and a high degree of disability. Non-invasive bladder cancer - superficial tumors of the mucous membrane of the bladder with possible germination in the submucosal layer, but without muscle invasion (pTa and pT1). Invasive bladder cancer - with germination in the muscle layer (≥рТ2). Currently, there is an extensive literature on genetic data with RMP T2-T4, but there is not enough information about the early form of RMP - T1. It was discovered that almost 90% of the human genome is actively transcribed, while only 2% are protein-coding genes, and the majority of the transcripts are non-coding RNAs. Molecules of non-coding RNA, depending on their size, are divided by length. A lot of data has been published regarding the effect of short variants of these molecules on the development of oncopathology by inhibiting mRNA expression. At the same time, we did not find large studies devoted to the study of the influence of long noncoding RNAs. Also now, the MALAT1 dnaRNA is attracting the attention of scientists. Concurrently, researchers are particularly interested in studying the relationship of single nucleotide polymorphisms of the MALAT1 gene with the appearance of oncopathologies of different localization, as well as the study of its association with different characteristics and stages of the tumor process. In this study, we collected overview data regarding the possible association of rs 3200401 polymorphism of the MALAT1 gene in patients with a single focus and multifocal bladder cancer stage T1.

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