Introduction: Neck pain or cervical pain is a common musculoskeletal disorderassociated with degenerative processes in muscle, connective tissue, and nerve tissue. The cliniciansassess theassociated impaired function in neck pain patients. There is a lack of clarity in the superiority of the specific application of various exercise protocols. McKenzie protocol is commonly prescribed by physiotherapists as being effective. Objective: To evaluate the effect of McKenzie protocol for patients suffering from chronic mechanical cervical spine pain. Methodology: The study design comprises aquantitative research approach with pre and post-test control group design. It was conducted in a selected rehabilitation center, Bhubaneswar, Odisha. The study sample included 60 mechanical neck pain individuals, 30 in each experiment& control group. Random assignment with a purposive selection of the samples was taken for the groups. The structured interview schedule for background data, structured pain assessment proforma, the visual analog scale, and the neck disability index were used as tools for gathering necessary data for neck pain from the samples. The McKenzie protocol compared with the control group was noted for pain intensity as well as NDI were assessedfor two weeks. The analysis and interpretation of obtained data were performed byfollowing descriptive and inferential statistics in terms of frequency, percentage, mean, median, and “t” value. The “t” test was applied to compare the pain in pre- and postinterventions. A p-value of alfa < 0.05 was taken as the level of significance.Results: It was found that; there was significantly lower in the mean post test scores than the mean pretest VAS, as well as NDI scoresof the experiment group. The Mean posttest VAS scores of the experiment group (5.733) and the control group (4.867) with a mean difference of 0.8667 were found to differ significantly as evident from the 't' = 2.561 at df, 28 at α=0.05 level. Apart from this the mean posttest (16.33) pain scores by NDI of the experiment group and control group (13.33) with a mean difference of 3.0, having 't' = 2.757 at df, 28 differed significantly at α= 0.05 level. Conclusion: McKenzie protocol was found to reduce mechanical spine pain and alleviated the condition, and thus would be very helpful in the management of neck or cervical spine pain.