Solubilizations of the poorly drugs soluble is one among the most important physicochemical characteristics for the drug development process as from the available drugs one-third of drugs are poorly water soluble or insoluble. Most of the approaches used to increase the solubility of poorly soluble drugs are used of many solvents, increase of main surface area by reduction of it size, salt form selection, change of crystal form, complex formation with the excipients as hydrophyllic polymers and change in preparation of solid dispersions