Abstract - In this paper, efficient production of ethanol from corn by using fermentation process is discussed. A mathematical model is developed for the above-mentioned process and the challenges in adjusting the specific growth rate(µmax) has been addressed. Also, the rate or velocity of growth of the microbial cells which is the key affecting factor of the substrate concentration is adjusted for optimum results. On successful design of the mathematical model, the concentration of ethanol is controlled by using four different controllers out of which one suitable controller is considered as the ideal controller for the production of ethanol from corn.