In quest of some anti-Novel corona activity drugs, molecular docking studies with PDB ID 6LU7 were carried out using certain well known chloroquine and its derivatives viz Hydroxychloroquine Mefloquine. Molecular docking has been done in order to search the best drug candidate among chloroquine derivatives. The molecular dockings were done in Argus lab. Molecular docking studies revealed that chloroquine found effectively inhibit the recently emerged novel coronavirus . The docking score for chloroquine, Hydroxychloroquine Mefloquine found to be -8.55665, -8.30357, -7.98409 respectively. Chloroquine is found to be best drug candidate among its derivatives with docking score of -8.55665.