Primum non nocere is a principle proclaimed by Hippocrates and remains relevant throughout the history of medicine. Unfortunately, pharmacotherapy does not always correspond to it. Although modern oral antibacterial drugs generally have a favorable safety profile, there are still many side effects. Antibacterial, like all medicines, have side effects, some of the side effects can be serious and some are dire. The use of antibacterial drugs in all areas of medicine, often unreasonable indications for their use, free access for the potential consumer - all this leads to irrational use of drugs, starting from an early age. More than 50% of diseases are infectious in nature. Infectious drugs account for 20% of all drugs currently used in medicine. The misuse of antibiotics is fraught with the development of antimicrobial resistance in the pathogen.