The success of root canal treatment depends on thorough disinfection of the root canal system, and to provide fluid impervious seal which in turn halt the progress of the periapical infection. The oral microorganisms from the degenerated pulp tissue are responsible directly or indirectly for most of the periapical lesions. For the treatment of these lesions there are surgical and non-surgical methods. Surgical removal of the periapical lesion without proper root canal disinfection and obturation will result in improper healing of lesions whereas in non-surgical root canal therapy the lesions heal if proper cleaning, shaping and obturation of root canal are done. This clinical case series highlights the follow-up results of three cases demonstrating the resolution of periapical lesion through nonsurgical approach and confirms that periapical lesions respond favorably to non-surgical treatment.