Suction is a procedure of action in health services that affect the safety of the clients because suction aims to assist clients to fulfill the oxygen needs by helping to liberate the airway. This study aimed was to gain an overview of the nurse's experience of determining how to perform suction actions on clients with mechanical ventilators in the Intensive Care Unit (ICU). A qualitative research method with phenomenology design. The data were collected by in-depth interviews on 26 participants who worked as nurses in the ICU. There were seven themes identified in this study: (1) the understanding of suction; (2) the experience of suction; (3) the suction complication; (4) the pathophysiology of ventilator installation; (5) the importance of adequate resource support; (6) the nurse constraint in the suction implementation; and (7) the protection against nosocomial infections. The hospital can improve the support of nurses on their self-development and caring skill in accordance with the standards, in order to continue to gain skills and can update the latest health sciences to support the procedures performed in the ICU.