Globally, oral cancer is the sixth most common cancer and it is associated with a mortality rate up to 50%. Oral cancer usually encompasses tumours derived from the lips, anterior two-thirds of the tongue, buccal mucosa, hard palate, the floor of mouth, upper and lower alveolar ridges, retromolar trigone, and sublingual area. An approximate age-standardized to world population (ASR (W) for oral cavity and lip cancer according to the World Health Organization (WHO) the topmost is South East Asia with incidence of 6.4 per 100000, followed by Europe and East Mediterranean (4.6 cases per 100000), America (4.1 per 100000), Africa (2.7 per 100000), and Western Pacific area (2.0 per 100000).Oral squamous cell carcinoma has multifactorial pathogenesis which includes smoking, alcohol consumption, and HPV and others. Oral cancer has multifactorial etiology, mainly smoking, tobacco, alcohol consumption, betel quid chewing and high-risk human papillomavirus (HPV). Worldwide, the prevalence of HPV infection is 3% in oral cavity cancer and has a significant role in the management of oral squamous cell carcinoma (OSCC) as HPV-related oral cancers have shown better prognosis. The risks of oral cancer in many developing countries had increased mainly by the habits of using betel quid chewing, tobacco and alcohol consumption.Human papillomavirus is a major concern and a public burden in a clinical setting all over the world. The sites frequently involved in HPV related cancers are tonsils and base of the tongue.