The present study is aimed to analyse the ethanol and aqueous extracts of leaves of Azardirachta indica, Vitex nigundo and seeds of Trigonella foenum graecum through FTIR spectroscopy method. The FTIR spectroscopic studies revealed different characteristic peak values with different functional groups in the extracts. The FTIR analysis of leaf extracts of Azardirachta indica, Vitex nigundo and seeds of Trigonella foenum graecum extract confirmed the presence of amide, alcohols, phenols, alkanes, carboxylic acids, aldehydes, ketones, alkenes, primary amines, aromatics, esters, ethers, alkyl halides and aliphatic amines compounds, which shows major peaks. The FTIR method was performed on a spectrophotometer system, which was used to detect the characteristic peak values and their functional groups. The results of the present study generated the FTIR spectrum profile for these medicinally important plants and these can be used in the industry. The nature of therapeutic action of theseplants as understood from its chemical properties could be a novel approach in developing cost effective and safe herbal formulations to deal with dermal disorders.