The aim was to study the prevalence and risk factors of dental disease development in pregnant women living in different Uzbekistan regions. The prevalence and intensity of dental caries among pregnant women are 1.3 times higher in the Urgenchdistrict of the Khorezm region compared to the Kibray district of the Tashkent region. These figures increase with each subsequent pregnancy. The same pattern is observed for periodontal and oral mucosa diseases. The most significant medical and biological factors contributing to the development of dental diseases in pregnant women were age, several pregnancies, intergenerational period, course and terms of pregnancy, the presence of extragenital diseases. Among medical and social risk factors, the most significant were education, living conditions, oral hygiene, sanitary culture, and medical activity of pregnant women.