The present study was aimed to study relationship between physical activity and General mental health among chronic psychiatric patients. A sample of 200 chronic psychiatric patients (100 male patients and 100 female patients) was selected by non probability purposive sampling technique method. The sample taken were chronic psychiatric patients who attended psychiatric OPD and day care centre from, selected hospitals Pune. The patients who were diagnosed as mentally ill for more than 2 years were selected for the study. Their age was between 20 to 60 years. They responded to two tools International Physical Activity Questionnaire Scale by Craig, Marshall, Sjostrom, Bauman, Booth, Ainsworth & Oja et.al. (2003) and General Health Questionnaire by Goldberg & Williams (1970). The statistical tool Pearson’s product moment correlation method was used to find the correlation between physical activity and general mental health among chronic psychiatric patients. Another statistics independent‘t’-test was used to study the gender difference in physical activity and general mental health among chronic psychiatric patients. The results showed that there is negative correlation (‘r’=-0.606) found between physical activity and general mental health among chronic psychiatric male and female patients at 0.01 level of significance. There is gender difference (‘t’=1.99) found in physical activity among chronic psychiatric patients. There is gender difference (‘t’=3.27) found in general mental health among chronic psychiatric patients. Although the differences is minimal. There is a moderate level of physical activities found in females and the general mental health of females is found higher than the males and also the negative correlation explains that the amount of physical activity is not related to the mental health of the psychiatric patients, as the chronic psychiatric patients physical activities are more of household, work related and transportation based and not recreational physical activity. Hence health personnel’s have to plan the home based care with recreational activities to improve mental health of the patients at home.