Background: A review of renal biopsy data gives insight into the spectrum of clinically significant renal disease and necessary epidemiological data on renal diseases. Objectives: to analyze the histopathological spectrum of native kidney biopsies in the north Karnataka population. Material & Methods: A total of 772 patients who underwent kidney biopsies at Department of Nephrology KIMS Hubli from January 2000 to December 2020 were included in the study. Results: The mean age of patients was 36.77+25.15 years. The most common histopathological diagnosis made was of primary glomerular disease (57.77%), followed by Tubulo-interstitial disease(17.61%), while the least common was the vascular disease (1.8%). Glomereular disease is the most common histopathological finding among renal biopsies. Among primary glomerular diseases Minimal change disease was the most common finding noted in 23.31% of cases followed by Focal segmental glomerulosclerosis(18.16%),IgA nephropathy (14.57%),Membranous GN(11.88%), Membrano proliferative GN(10.98%), Mesangiocapillary GN (10.76%),Complement mediated GN (5.1%), Crescentic GN21 (4.7%), IgM nephropathy (0.4%)was the least common finding among glomerular diseases