Abstract Orofacial infections of odontogenic origin have long plagued mankind. The discovery of the miracle drug by fleming in the year 1928 and the routine use of penicillin after the landmark discovery of the powder form of the antibiotic by florey and chain leading to significant change in the management of odontogenic infection .The spread of infection is governed by factors such as impaired host defence, the virulence of microorganism, functional abnormalities of the host and a lack of or delayed treatment. the microbiology of odontogenic infections in diabetic and non-diabetic individuals has been found to be variable. Though the effects of diabetes can affect infection severity , length of hospital stay, susceptibility to antibiotics and outcome of treatment is unassured . Differentiation in antibiotics prescribed is also observed.The aim of the study was to analyse the prevalence of the use of antibiotics among diabetic and non-diabetic patients in a south indian dental university clinic . The list of all diabetics and non diabetics patients treated for pain, dental infections , swelling were retrieved by reviewing 86000 patient records who have visited the hospital during the study periods from june 2019 to march 2020 from the university database.Data tabulation was carried out in Excel. The data was imported and transcribed in Statistical Package for Social sciences version 16(SPSS,IBM corporation). Descriptive analysis was carried out.A total of 9128 patients were included in the study based on treatment done of which 580 patients(6.3%) had diabetes mellitus. Only 3.5 % of the male population and 2.8% of the female population has diabetes.Amoxicillin 93.2% was found to be the most frequently prescribed antibiotics among nondiabetic patients and diabetics patients 1.6% .A combination of metronidazole and amoxicillin was prescribed to 0.5% of the whole study population .A combination clavulanic acid and amoxicillin(augmentin )was prescribed to 4 % of the total diabetic study population and 0.4% of the nondiabetic study population that is about.The relation between the diabetic status of a patient and the antibiotic prescribed showed a significant statistical relationship in a Pearson's Chi square test with p value of 0.001(p<0.005).The prescribing practises in dental offices can be improved by increasing awareness among dental practitioners about the recommended guidelines for prescribing antibiotics . The most commonly prescribed antibiotics among diabetic patients was Augmentin (4.08%) and for non diabetics it was amoxicillin (93.25%). .