Tuberculosis is a global health crisis; it is estimated that 25% of the world’s TB cases are found in India. DOTS strategy was launched in 1994 and became the global recommendation for TB control. Ayurveda, an ancient health science may offer some solution, several studies conducted in Ayurvedic colleges and hospitals in the management of the disease. This is the systemic review of such studies to assess the role of Ayurvedic medicine in the management of Rajayakshma (Pulmonary Tuberculosis)