Pratishyaya is one of the disease which leads to immune- deficiency condition in its chronic phase. If it is not treated in time it leads to severe disorders like asthma and other complicity disorders of respiratory tract. So treatment in early stage of disease is necessary. In Ayurveda, Panchkarma therapy is used for the maintenance of health and eradication of diseases from their root and Nasya Karma is one among them. In this therapy, the medicine is administered through nose either in the form of ghee, oil, powder, liquid or smoke. In this case study we advocate Pradhaman Nasya chikitsa for the management of Paratishyay .