Background: Lung transplantation is the choice of therapy in severe cases of idiopathic pulmonary fibrosis (IPF) but is compounded with post-transplant complications. The paucity of deceased organ donations underlines the need for alternate approaches that improves the quality of life. Herein, we attempted to develop an autologous adult bone marrow derived mesenchymal stromal cell (BMSC) therapy via central line access, and evaluated the safety of a single dose (~13 × 106 cells/mL), in treating “no option” IPF. Method: The study included severe IPF subjects (n = 6) both male and female, aged 40–70 years of age with a forced vital capacity < 50%, diffusing capacity of lung for carbon monoxide (DLco) < 35% of predicted, and/or oxygen (SpO2) saturation < 88% on 6 min walk distance (6 MWD). BMSCs at passage 2 were suspended in 30.0 mL normal saline and dispensed through the central line route in a respiratory intensive care unit of Gleneagles Global Hospitals. The subjects were monitored for the first 24 h for serious adverse events and hemodynamic parameters. They were followed up periodically at intervals of 1, 4, and 9 months for safety and monitoring of adverse events, including secondary objectives of changes in pulmonary function test, DLco, 6 MWD, and quality of life as per the study protocol