Objectives: Find out the effect of structured teaching program on knowledge regarding self-care management of diabetes mellitus among the diabetic patients of the selected community area, Khordha, and to determine the association between post-test scores with selected sociodemographic variables. Methods: In this study Quasi-experimental (one group pre and posttest) design was used. Purposive type of sampling technique was used to select fifty no. of diabetic patients of a selected area of Khordha, Odisha as study sample, and Self-structure close-ended multiple-choice questionnaire was used to the collection of information. Result: There were maximum respondents (36%) were within 35-40 years of age. The majority (54%) were males. According to religion, the maximum (96%) were Hindu. According to Educational status, maximum (64%) were graduate. According to previous exposure to STP on self-care management of DM, maximum (84%) were having no previous exposure and analysis is revealed that structured teaching program improved the knowledge of diabetic patients regarding self-care management of diabetes (before intervention 11.66±2.2 & after intervention 23.08±2.31) significantly as calculated “t” value is 34.92 & calculated p-value was ˂0.0001 which is less than 0.05 level of significance. A statistically no significant association was there in between the knowledge score of DM affected people on a structured teaching program of DM with a sociodemographic variable. Conclusion: On the finding of the study, it was found that a structured teaching program is more practical in upgrading the knowledge of patients on self-management of diabetes which ultimately can improve their health status.