Pulmonary Tuberculosis (Pulmonary TB) is a type of chronic infectious disease that threatens public health. Self-management is a form of patient self-control in the treatment and cure of TB disease. The aim of the study was to see the self-management of patients in the pulmonary TB treatment program from the aspects of patient interaction with health care facilities and patient compliance in taking TB drugs in Kupang City, East Nusa Tenggara Province, Indonesia. Non-experimental research design with cross sectional design. The number of samples was 246 TB patients. Sampling with cluster sampling technique. Data were collected directly on patients and study documentation of patient care in public health centers. Data were analyzed descriptively and correlated using the Spearman rho test (α <0.05) The results showed the interaction of patients with health care facilities; good 38.2%, good enough 56.6%, not good 5.3%. Patient adherence to ingesting TB drugs; obedient 88.6%, non-compliant 11.4%. Correlation test of patient characteristics on interactions with health care facilities; age 0.07, gender 0.24, education 0.01, TB treatment stage 0.76, distance from home to public health center 0.00. Correlation of patient characteristics with adherence in ingesting TB drugs: age 0.76, gender 0.62, education level 0.55, TB treatment stage 0.00, distance from home to public health center 0.02. Conclusion Self-management of patients in the TB treatment program from the aspect of patient interaction with health care facilities is quite good, patient adherence to ingesting TB drugs is adherent. Factors related to self-management of patients are the level of education, the stage of TB treatment, and the distance from the house to the health care facility.