Lead and its compounds are continuously detected in environmental objects at various concentrations and doses. Lead is a general plasma poison that affects the nervous, bone, endocrine system, blood and blood vessels, parenchymatous organs, gastrointestinal tract, metabolism, reproductive function, immune status and resistance. In this regard, there is an acute need to study in the experiment features of the response of the body of rats at the same time aerogenic and oral intake of lead and the development of its permissible values in the air, water and food products, taking into account the complex effects. Objective: to determine experimentally the peculiarities of biological response of experimental animals at simultaneous aerogenic complex intake of lead and development of its permissible values in air, water and food products. Methods: Concentration (dose) - time-effect relationship was used. For inhalation, 200-liter chambers were used in the experiment, proposed by B.A. Kurlyandsky. Modern highly sensitive biochemical, physiological, gonad and embryotoxic indicators were used to assess the resorptive toxic effect of lead.