Objective: Dengue fever is the most common arbovirus borne illness known to humans with mortality reaching 20% without treatment. The current study was designed to assess clinical profile and presentation of dengue fever Method: prospective observational study done in Nalanda Medical College and Hospital (NMCH), Patna . 224 patients with confirmed dengue were included and clinical, hematological, biochemical and radiological parameters were noted. Result: Male preponderance was seen with maximum cases below 30 years of age. Maximum patients required admission for less than 10 days. Fever, nausea, vomiting, headache, loose stools, bleeding, cough, pain abdomen and loss of appetite were the commoner presenting complains. Thrombocytopenia was found the most consistent laboratory finding followed by leucopenia and raised liver enzymes. Radiological findings were rare. Mortality rate was nil. Conclusion: Fever, gastroenterological symptoms and bleeding with low platelets, low leucocytes and raised liver enzymes should prompt the physician to look for Dengue infection. With timely diagnosis and proper management the prognosis of the disease is good.