Online ISSN: 2515-8260

Study of Comparing the Efficacy of Intravenous Levetiracetam Versus Intravenous Valproate inthe Management of Refractory Status Epilepticus in Children

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U Ashok Kumar1

Abstract

Background: Primary: To compare the rates of clinical seizure cessation at 15 min after intravenous bolus infusion in the two groups (valproate versus levetiracetam) of children aged 1-12 years with refractory status epilepticus (uncontrolled with initial BDZ and phenytoin bolus). Materials and Methods: This study was conducted in Department of Pediatrics, Mamata medical college and General hospital Khammam. Study Period: Oct 2017 to Sept 2019. Study population: Children between 1 to 12 years with status epilepticus who had received diazepam followed by phenytoin infusion of 20 mg/kg and repeat 10 mg/kg. If status was still not controlled, they were labelled as refractory status epilepticus and enrolled in study. It was a Randomised controlled study.During the study period(Oct 2017to Sept 2019) a total of 1835 children visited emergency room, at our centre. Among them 259 children had seizures presenting feature. Fifty-seven children met the criteria for enrolment. Seven of these children could not be randomized. The remaining fifty children were randomized into two groups- group A received valproate (n=25) and group B received levetiracetam (n=25).

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