Lemongrass (Cymbopogon citratus) is a rich plant containing compounds called polyphenols, especially flavonoids. Lemongrass has been widely used in many counytries as antiinflamation, antibactaria, antifungal, antidiarhoea and as repellent to insect also proven to lower blood glucose. This study aims to determine the effect of the ethanol extract of lemongrass on blood lipids profile using 25 male albino rats Wistar strain, were devide into 5 groups, each group consisted of 5 rats, namely the control group (K), the standard group (S) and the treatment group ES100, ES200 and ES400. All rats made hyperlipidemic by administration of diet high in fat and egg yolk for 14 days, then assayed lipid profile include total cholesterol, LDL, HDL and triglyceride (pre test). Furthermore, the group K were without treatment, Sim group were give drug standard simvastatin 0,18 mg/200g bwt, ES100, ES200 and ES400 group treated with ethanol extract of lemongrass respectively 100, 200 and 400 mg/kg bwt with sonde for 14 days. On the 15th days all rats were fasted and then have blood drawn through orbital venous and made serum and defined serum lipid profile (post test).