Background: Birth asphyxia resulting in hypoxic-ischemic encephalopathy (HIE) remains a major cause of neonatal mortality and morbidity worldwide. Different organ systems of the body are affected in birth asphyxia, liver being one of them. Method and Material: Full term neonates with APGAR score of ≤7 at five minute of life or Failure to breath spontaneously immediately after birth or Requiring resuscitative measures to sustain life after birth; Along with Umbilical cord pH <7 or base deficit ≥16mmol/lt were included. Neonates with Major congenital malformation, chromosomal abnormalities, Birth trauma and Sepsis were excluded. APGAR was recorded at 1st, and 5th minute of life. Cord blood ABG was done to diagnose perinatal asphyxia. Neonates were grouped according to Sarnat and Sarnat stages of HIE. Serums AST, ALT, ALP of asphyxiated neonates were estimated between 48 to 72 hours of life.