Background and Objective: The research will link these parameter levels and predict asthma severity to assist clinicians diagnose and treat asthma and avoid abrupt and severe airway blockage in patients with hyperirritability of airways and other allergic disorders, which are at high risk for deadly asthma. Method: Department of Biochemistry, Osmania general hospital, Hyderabad, Telangana, India, conducted the investigation on 80 asthmatics and 40 controls who participated in the research. Total Cholestrol, Triglycerides, HDL, LDL, VLDL, Calcium, and Iron were measured. SPSS 17.0 was used to statistically examine the data. Result: In stable asthma patients, Cholesterol, LDL, Triglycerides, Calcium, Iron, and HDL were significantly correlated. Exacerbating asthma had lower serum very low density lipoprotein, higher serum calcium levels and has higher serum iron concentrations than stable asthma. Conclusion: In order to help doctors in the diagnosis and treatment of asthma and avoid abrupt and severe airway obstruction in hyperirritable airways, the current research examined lipid profile, calcium, and iron in aggravating and stable asthma patients.