Background &Method: The aim of the study is to determine lipid status in one of the common neurodegenerative disease i.e Parkinson’s disease patients. 5 ml fasting blood samples from patients sex & age matched controls were collected from antecubital vein, with all aseptic precaution in plain vacutainers. Result: Serum total cholesterol level and LDL cholesterol was significantly low in Parkinson’s patients as compared with control group. Serum HDL cholesterol level was slightly low, but not significantly different as compared with controls. Conclusion: Finally from our work we observed that Serum Total cholesterol and Serum LDL cholesterol levels are significantly decreased, in Parkinson’s disease patients as compared with controls. Serum HDL cholesterol is slightly decreased & did not show any statistical difference in Parkinson’s disease patients as compared with healthy controls suggesting dysregulation of lipid metabolism in PD patients.