ABSTRACT: The aim was to study the clinical profile and predictors of in-hospital outcome in critically ill patients with T2DM admitted in MICU. It also aimed to study the predictive value of different critical care scoring systems in T2DM patients. A prospective, cross sectional and observational study was conducted in General Medicine Department, “Dr. D. Y. Patil Medical College and Research Centre, Pimpri, Pune, India,” between September 2020 to October 2022 with a sample size of 80 T2DM cases and 80 non-T2DM controls. Overall maximum number of study participants belong to the age group of 50-69 years, Patients with T2DM had higher chances of a prolonged ICU stay and a higher mortality rate due to their critical illness compared to the non-diabetic patients. However, their mortality rate was not associated with prolonged duration of ICU stay.All the major vital parameters and biochemical parameters including RFT, Serum electrolytes, Serum Lactate and Serum Pro-calcitonin were significantly worse in diabetic patients compared to non-diabetic patients at the time of admission to the MICU.APACHE IV, SAPS3 and SOFA scores were worse on the day of admission in the T2DM patients compared to the non-diabetic patients. Except MODS all scores on day 1 and on the day of outcome were worse in diabetic patients who died in the ICU. In conclusion APACHE IV has a good predictability over SAPS III, SOFA and MODS in critically ill T2DM patients.