Background: Thyroid dysfunction with metabolic syndrome is recognized risk of atherosclerotic and cardiovascular disease. This study is an effort to investigate the proposed association between these two disease entities and to identify the factors that increase the risk of this association. Methods: A cross sectional study from a teaching hospital in Bhopal city of central India. Total80 patients with metabolic syndrome were included in this study. Metabolic syndrome patients required to fulfil NCEP-ATP III criteria and 80 patients without metabolic syndrome were allocated into the control group. The biochemical parameters like: Fasting Glucose, Lipid Profile, Thyroid Profile, Hs-CRP, FINS, HOMA-IR levels were determined for assessment of metabolic dysfunctions