Background:The recent development of LCP has revolutionized the surgical treatment of fractures by overcoming the few drawbacks of older internal fixators. The fractures of the shaft of humerus are one of the commonest fractures found and the accepted management for fractures shaft of humerus is open reduction and internal fixation using compression plating. Our present study is aimed at the assessment of results of plate osteosynthesis of diaphyseal fractures of humerus using locking compression plate and to assess the functional recovery with this procedure. Materials and Methods: It is a prospective study which was carried out from December 2019 to June 2021 atDistrict Hospital, Eluru. In this study period 20 cases of fracture shaft of the humerus were treated by open reduction and internal fixation using Locking Compression Plate.