Abstract: Background: Osseous resection is established treatment protocol for periodontal hemiseptal defects, however this forces clinician to settle for less than optimal results and leads to undesirable outcomes like unpleasant esthetics, denitinal hypersensitivity, root caries etc. the present treatment protocol is designed to asses defect resolution by autogenous bone pieces in treatment of periodontal hemiseptal defects. Objectives: To evaluate the soft and hard tissue response using clinical parameters like probing pocket depth(PPD), clinical attachment level(CAL) and radiographic bone fill in treatment of hemiseptal periodontal defects to Open flap debridement, Osseous resective surgery autogenous bone graft. Methods: the study sample will be randomly divided in to 3 groups of 12 hemiseptal defects each. Group 1 to be treated by resective osseous surgery, Group II treated by open flap debridement and Group III treated by Autogenous bone graft. Clinical parameters include gingival index, probing pocket depth and clinical attachment level along with radiographic assessment with radivisograph (RVG) and cone beam computed tomography (CBCT). All parameters will be evaluated at baseline, 3, 6 and 9 months interval. The Independent-Samples t Test will be done to compare means for two groups.” The Paired-Samples t test to compare means of two variables for a single group. Difference will be considered significant when p value <0.05. Expected results: Proposed approach is expected to show improvement in probing pocket depth, clinical attachment level, and gingival index. It is also expected to gain defect fill reduction or resolution of hemiseptal defect. Conclusion : By attempting to treat periodontal hemiseptal defects with regenerative method this study is attempting to avoid all undesired effect associated with osseous resection and provide evidence of regeneration in such defects, this can lead to paradigm shift in treatment approach of periodontal hemiseptal defects.