Introduction: Diabetic foot has become the common indication for hospital admissions among diabetics. The diabetic foot commonly begins as an ulcer. So rapid and extensive is the underlying damage that approximately 20% of these patients end up with amputation. The present study has been performed to compare the efficacy of collagen dressing with that of conventional dressing materials like silver sulfadiazine, nadifloxacin, povidone iodine. Materials and Methods: Fifty patients (40 males and 10 females) were procured to be included to experimental group who were treated using collagen dressing and they form the study group. Control treatment was performed on 25 patients (21 males and 4 females) at the same period. All the quantitative values were noted as mean± standard deviations.