Abstract The care and protection of people with disabilities are handled by various governmental and non-governmental organizations. In this paper, the authors have illustrated some of the innovative practices and programmes that would be beneficial for the disabled categories. Though the paper is a conceptual one, the content such as the various practices and programmes have clearly on empirical aspects. The community assessment, communitybased rehabilitation, self-employment and microfinance, vocatidional rehabilitation and training, assistive devices with technologies etc are discussed in this paper. It is evident that various non-governmental organizations have effectively contributed for the care and protection of the disabled people. The paper focused on the present situation of disabled people in India, especially the state of Kerala. The implication and discussion part has extensively discussed the various practices and programmes run by the non-governmental organization.