was prepared from the reaction of compensated aniline with potassium thiocyanate in the presence of bromine. Unsaturated Alpha-Beta (E2-6) compounds were obtained from the reaction of aromatizing aldehydes with para –hydroxyacetophenone in a basal medium. The interaction of alpha-beta - unsaturated compounds with 4,6-dichloro-2-aminobenzothiazole gives compounds (E7-11) 4-(1-(4,6-dichlorobenzothiazole-2-El amino) - 3-aryl) phenol. The bioavailability of compounds prepared on two types of Gram-negative and Gram-positive bacteria was tested using a lower inhibitory concentration and compared with standard antibiotics. The prepared compositions were validated using physical and spectral methods using FT-IR,H1- NMR,C13NMR technology