Background: Diabetic nephropathy is accounts for mortality and morbidity among more than 20% of patients with diabetes mellitus. This rising prevalence depends on various factors such as, sedentary lifestyles, rapid urbanization, unhealthy diets and substance use/abuse along with increasing life expectancy. Obesity and overweight are also the most important associated risk factors. The onset of diabetes can be prevented or delayed by life style and behavioral changes by taking healthy diet and routine physical activity. Material & Methods: The present case-control study was conducted at department of Department of Medicine of our tertiary care hospital. The study duration was of one year. Patients were enrolled from outdoor and from ward by simple random sampling. Clearance from Institutional Ethics Committee was taken before start of study. Written informed consent was taken from each study participant. Recently diagnosed (<3 months), adults ( >18 years), T2DM patients were enrolled in the present study. Results In the present study, out of the total study participants on assessing multi-variate logistic regression for risk factors for diabetic nephropathy among newly diagnosed T2DM subjects we found that age (OR:0.34; P value >0.05), sex (OR:1.19; P value >0.05), smoking (OR:1.32; P value >0.05), BMI (OR:0.56; P value >0.05) and HbA1c levels (OR:2.04; P value >0.05) had statistically non-significant association. Hypertension (OR:2.98; P value <0.05), Family history of diabetes mellitus (OR:1.46; P value <0.05), presence of diabetic retinopathy (OR:2.12; P value <0.05) and Family history of diabetic nephropathy (OR:2.43; P value <0.05) had statistically significant association for diabetic nephropathy among newly diagnosed T2DM subjects.Conclusion: Hypertension, Family history of diabetes mellitus, presence of diabetic retinopathy and Family history of diabetic nephropathy had statistically significant association for diabetic nephropathy among newly diagnosed T2DM subjects.