Introduction: The first year of medical course is taught mainly by didactic lectures and tutorials with no exposure to patients. The Early Clinical Exposure helps medical students to create more interest in basic subjects, strengthen learning and make learning more real and relevant. Since our study was planned to evaluate the effectiveness of Early Clinical Exposure compared to conventional teaching methods. Objectives: To assess and compare the acquired knowledge of students from didactic lecture and early clinical exposure Materials and methods: 100 first MBBS students were divided into two groups of 50. Study group for anaemia served as control group for jaundice and vice versa. Study group students were taken to medicine ward for giving short description about anaemia followed by clinical examination. Control group students were taught by lecture. Both were assessed by pre-test and post- test questionnaire. Crossing over of groups was done with jaundice in next session. Test scores statistically analysed with SPSS. Results: Mean pre-test and post-test scores of students learning improved significantly from 2.240±0.771 to 8.140±2.399, (P < .00001) in the anemia study group 3.18±1.804 to 9.2 ±2.441 (P < .00001) in jaundice study group. There was statistically significant improved performance in early clinical exposure sessions when compared to lectures. Conclusion: The first year MBBS students’ ability to understand clinically relevant concepts has been improved by Early Clinical Exposure. Students and faculties found ECE is a useful method if it is taken with traditional teaching learning methods.