The first 1000 days of life are very important times for children's brain development. Providing good nutrition and maximum stimulation will be able to help the child's maximum development. UNICEF and WHO recommend exclusive breastfeeding for infants carried out until the baby is 6 months old, but until now the achievement rate for breastfeeding is still low. In Indonesia the achievement of exclusive breastfeeding in 2018 only reached 65.16%. The low achievement of breastfeeding is influenced by many factors of mother's knowledge, mother's occupation, the provision of appropriate information and family support. The family here is not only husband or partner but also grandmother both maternal grandmother and paternal grandmother. Many studies have suggested that grandmothers have a considerable influence on the success of breastfeeding. The purpose of this systematic literature review is to review some of the literature on the effect of a grandmother's involvement in breastfeeding success. The method used in the Systematic literature review is to collect literature from 3 databases namely PubMed, Science Direct and ProQuest. The articles used are from 2010-2020, with a total number of articles of 2973 articles. Obtained 14 selected articles that have met the specified criteria. The influence of grandmother's involvement in breastfeeding success is divided into 4 topics, namely: (1) grandmother's knowledge, (2) living with grandmother, (3) health education involving grandmother, and (4) grandmother's support. Grandmother's correct knowledge of breast milk increases optimal breastfeeding, giving colostrum, the right time in feeding replacement milk. Mothers who have a high frequency of contact with grandmothers show that it is associated with low rates of breastfeeding, and short feeding times. Providing health education to mothers by involving grandmothers were cohibiting with mothers shows a low rate of breastfeeding replacement. Providing support by grandmothers is directly proportional to support from ethnic groups, the existence of support from grandmothers increases the rate of breastfeeding to infants. Grandmother's involvement greatly influences the success of breastfeeding to mothers, it needs to be considered to start involving grandmothers in the provision of health education to mothers so that success can be achieved exclusively breastfeeding.