Abstract: Cardiomyopathy is a severe pathology, which requires careful study of clinical parameters and data of functional diagnostics methods (ECG, ECHO) for early detection. The study aimed to study the role of clinical and instrumental, biochemical, and immunological investigation methods for early detection and prognosis of cardiomyopathy course in children. Materials and methods of study: 85 children with cardiomyopathy under 18 years of age were examined, including 60 children with dilated cardiomyopathy (DCMP), 16 children with hypertrophic cardiomyopathy (HCMP) and 9 children with restriction cardiomyopathy (RCMP) who were hospitalized in the cardioreumatology department of the Republican Specialized ScientificPractical Medical Center of Pediatrics of the Ministry of Health of the Republic of Uzbekistan. The control group consisted of 30 practically healthy children.