Introduction: Postoperative pain management is essential for an early postoperative recovery. In spinal decompression surgery, nociceptive pain occurs due to surgical tissue injury to soft tissues and bony structures. And also manipulation of neurological tissue leads to neuropathic pain. Duloxetine (SSNRI) has an antinociceptive effect and it interfere with occurrence of chronic post surgical pain by modulating pain pathways. Duloxetine reduces acute postoperative pain as well as reduces dose of analgesic consumption.