Background & Method: The aim of the study is to study the functional involvement of kidney in leprosy patients in terms of Serum Creatinine. 70 Patients of, various age group ranging from 5 to 65 years were studied. out of which 53 patients were male and 17 patients were female. Creatinine reacts with picric acid in alkaline medium and form orange-red coloured complex formed , intensity of which is directly proportional to creatinine in the sample and measured at 520 nm